Interpreting an ERP implementation from a stakeholder perspective

ERP systems are software packages that enable the integration of transactions oriented data and business processes throughout an organization. ERP implementation can be viewed as an organizational change process: many problems related to ERP implementation are related to a misfit of the system with the characteristics of the organization. This article uses the evidence of a case study to uncover some important dimensions of the organizational change issues related to ERP implementation. The study shows how ERP implementation can impact the interests of stakeholders of the ERP-system and how these groups may react by influencing the course of events, for example by altering the design and implementation in ways that are more consistent with their interests. Understanding the possible impact of ERP on particular interests of stakeholders may help project managers and others to manage ERP implementations more effectively.

A framework and a tool to generate e-business options

In early stages, many organizations started to use the internet in more or less ad hoc and experimental ways. After this first stage of learning and experimentation there often arises a need for more systematic approaches to identify, order, and assess e-business options. This paper addresses this need and presents a framework as well as a tool supporting this framework, helping management to generate and order e-business options for their organization. The framework consists of two parts. The first part covers the identification of the dimensions of e-business options. Six dimensions are identified: external stakeholders groups, stakeholder statuses, channel strategies, communication modes, products/service groups, and product/service statuses. Users of this framework can apply these dimensions given the specific characteristics of the organization at hand. Subsequently, these dimensions are combined, generating, in many cases, a multitude of potential e-business options. The second part of the framework supports the process of ordering this large set of generated potential e-business options given certain criteria. This can be accomplished by ordering the dimensions as well as the elements along each distinguished dimension. Some of these elements are company-independent, while others are company-dependent. The framework is illustrated by a case study as a running example. We also offer a design of a tool supporting our framework. The framework focuses on e-business options between an organization and its current or new external stakeholders: possible internal e-business applications are excluded in this paper. The framework can be used as a tool for practitioners, such as consultants or managers, to generate e-business options for a company. They can use it -for example- in workshops to support idea-generation with respect to e-business planning in a creative and structured way. The framework also contributes to theory by providing a method that systematically offers new possibilities for using the internet. After the identification and the ordering of e-business options, the generated and ordered options have to be assessed and selected; this paper however, only focuses on the generating and ordering process.

Association between consumption of black tea and iron status in adult Africans in the North West Province: The THUSA study

The association between black tea consumption and iron status was investigated in a sample of African adults participating in the cross-sectional THUSA (Transition and Health during Urbanization of South Africans) study in the North West Province, South Africa. Data were analysed from 1605 apparently healthy adults aged 15-65 years by demographic and FFQ, anthropometric measurements and biochemical analyses. The main outcome measures were Hb and serum ferritin concentrations. No associations were seen between black tea consumption and concentrations of serum ferritin (men P=0.059; women P=0.49) or Hb (men P=0.33; women P=0.49). Logistic regression showed that tea consumption did not significantly increase risk for iron deficiency (men: OR 1.36; 95 % CI 0.99, 1.87; women: OR 0.98; 95 % CI 0.84, 1.13) nor for iron deficiency anaemia (men: OR 1.28: 95 % Cl 0.84, 1.96; women: OR 0.93; 95 % Cl 0.78, 1.11). Prevalence of iron deficiency and iron deficiency anaemia was especially high in women: 21.6 and 14.6 %, respectively. However, the likelihood of iron deficiency and iron deficiency anaemia was not significantly explained by tea consumption in sub-populations which were assumed to be at risk for iron deficiency. Regression of serum ferritin levels on tea consumption in women : 40 years, adults with a daily iron intak

Cofactor regeneration by a soluble pyridine nucleotide transhydrogenase for biological production of hydromorphone

We have applied the soluble pyridine nucleotide transhydrogenase of Pseudomonas fluorescens to a cell-free system for the regeneration of the nicotinamide cofactors NAD and NADP in the biological production of the important semisynthetic opiate drug hydromorphone. The original recombinant whole-cell system suffered from cofactor depletion resulting from the action of an NADP(+)-dependent morphine dehydrogenase and an NADH-dependent morphinone reductase. By applying a soluble pyridine nucleotide transhydrogenase, which can transfer reducing equivalents between NAD and NADP, we demonstrate with a cell-free system that efficient cofactor cycling in the presence of catalytic amounts of cofactors occurs, resulting in high yields of hydromorphone. The ratio of morphine dehydrogenase, morphinone reductase, and soluble pyridine nucleotide transhydrogenase is critical for diminishing the production of the unwanted by-product dihydromorphine and for optimum hydromorphone yields. Application of the soluble pyridine nucleotide transhydrogenase to the whole-cell system resulted in an improved biocatalyst with an extended lifetime. These results demonstrate the usefulness of the soluble pyridine nucleotide transhydrogenase and its wider application as a tool in metabolic engineering and biocatalysis